{"product_id":"medlife-paracetamol-650-mg-15tab-x-1s","title":"Medlife Paracetamol 650 MG DMF Grade - (15Tab x 1s)","description":"\u003cp\u003e\u003cstrong\u003eDETAILED DESCRIPTION\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003e: -\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAnti-pyretic, Analgesic\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eSymptomatic treatment of mild to moderate pain including\u003cspan\u003e a \u003c\/span\u003eheadache, migraine, neuralgia, toothache, sore throat, menstrual pains, Joint pains (arthritis), pains associated with influenza, fever and feverish colds.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMechanism of Action\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eP\u003c\/strong\u003e\u003cstrong\u003e\u003cem\u003eharmacodynamics:\u003c\/em\u003e\u003c\/strong\u003e\u003cem\u003e Mechanism of Action:\u003c\/em\u003e \u003cem\u003eAnalgesic:\u003c\/em\u003e The mechanism of analgesic action has not been fully determined. Paracetamol may act predominantly by inhibiting prostaglandin synthesis in the central nervous system (CNS) and to a lesser extent, through a peripheral action by blocking pain impulse generation.\u003cbr\u003eThe peripheral action may also be due to inhibition of prostaglandin synthesis or to inhibition of the synthesis or actions of other substances that sensitize pain receptors to mechanical or chemical stimulation.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eAntipyretic:\u003c\/em\u003e Paracetamol probably produces antipyresis by acting centrally on the hypothalamic heat-regulation center to produce peripheral vasodilation resulting in increased blood flow through the skin, sweating and heat loss. The central action probably involves inhibition of prostaglandin synthesis in the hypothalamus.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003ePharmacokinetics:\u003c\/em\u003e\u003c\/strong\u003e \u003cem\u003eAbsorption and Fate:\u003c\/em\u003e Paracetamol is readily absorbed from the gastrointestinal tract with peak plasma concentrations (C\u003csub\u003emax\u003c\/sub\u003e) occurring about 30 min to 2 hrs after ingestion. It is\u003cspan\u003e \u003c\/span\u003emetabolised\u003cspan\u003e \u003c\/span\u003ein the liver and excreted in the urine mainly as the glucuronide and\u003cspan\u003e \u003c\/span\u003esulphate\u003cspan\u003e \u003c\/span\u003econjugates. Less than 5% is excreted as unchanged Paracetamol. The elimination half-life (t\u003csub\u003e \u003c\/sub\u003e) varies from about 1-4 hrs. Plasma\u003cspan\u003e \u003c\/span\u003eprotein-binding\u003cspan\u003e \u003c\/span\u003eis negligible at usual therapeutic concentrations but increases with increasing concentrations.\u003cbr\u003eA minor hydroxylated metabolite which is usually produced in very small amounts by mixed-function oxidases in the liver and which is usually detoxified by conjugation with liver glutathione may accumulate following paracetamol overdosage and cause liver damage.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDosage \/ Direction for Use\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eMaximum dose in 24 hours: 6 tablets\u003c\/p\u003e\n\u003cp\u003eDo not exceed the stated dose.\u003c\/p\u003e\n\u003cp\u003eDo not take more frequently than every 4 hours.\u003c\/p\u003e\n\u003cp\u003eDo not take with any other product containing paracetamol.\u003c\/p\u003e\n\u003cp\u003eNot suitable for children under the age of 12 years.\u003c\/p\u003e\n\u003cp\u003eDo not take more than 3 days without medical advice.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eOverdosage\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eLiver damage is possible in adults who have taken 10 g of paracetamol. Ingestion of 5 g of paracetamol may lead to liver damage if the patient has risk factors.\u003cbr\u003e\u003cem\u003eRisk Factors: \u003c\/em\u003eIf the patient is on\u003cspan\u003e \u003c\/span\u003elong-term\u003cspan\u003e \u003c\/span\u003etreatment with carbamazepine, phenobarbitone, phenytoin, primidone, rifampicin, St John's Wort or other drugs that induce liver enzymes.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSymptoms:\u003c\/strong\u003e Paracetamol\u003cspan\u003e \u003c\/span\u003eoverdosage\u003cspan\u003e \u003c\/span\u003ein the first 24 hrs are pallor, nausea, vomiting, anorexia and abdominal pain. Liver damage may become apparent 12-48 hrs after ingestion. Abnormalities of glucose metabolism and metabolic acidosis may occur. In severe poisoning, hepatic failure may progress to encephalopathy,\u003cspan\u003e \u003c\/span\u003ehaemorrhage,\u003cspan\u003e \u003c\/span\u003ehypoglycaemia, cerebral\u003cspan\u003e \u003c\/span\u003eoedema\u003cspan\u003e, \u003c\/span\u003eand\u003cspan\u003e \u003c\/span\u003edeath. Acute renal failure with acute tubular necrosis, strongly suggested by loin pain, haematuria\u003cspan\u003e, \u003c\/span\u003eand\u003cspan\u003e \u003c\/span\u003eproteinuria, may develop even in the absence of severe liver damage. Cardiac arrhythmias and pancreatitis have been reported.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eManagement:\u003c\/strong\u003e Immediate treatment is essential in the management of paracetamol overdose. Despite a lack of significant early symptoms, patients should be referred to hospital urgently for immediate medical attention. Symptoms may be limited to nausea or vomiting and may not reflect the severity of overdose or the risk of organ damage. Management should be in accordance with established treatment guidelines.\u003cbr\u003eTreatment with activated charcoal should be considered if the overdose has been taken within 1 hr. Plasma paracetamol concentration should be measured at 4 hrs or later after ingestion (earlier concentrations are unreliable). Treatment with N-acetylcysteine may be used up to 24 hrs after ingestion of paracetamol; however, the maximum protective effect is obtained up to 8 hrs post-ingestion. The effectiveness of the antidote declines sharply after this time. If required the patient should be given intravenous N-acetyl cysteine, in line with the established dosage schedule. If vomiting is not a problem, oral methionine may be a suitable alternative for remote areas, outside\u003cspan\u003e the \u003c\/span\u003ehospital.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eContraindications\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eHypersensitivity to paracetamol or any of the constituents of Paracetamol-650.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSpecial Precautions\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eCare is advised in the administration of paracetamol to patients with severe renal or severe hepatic impairment. The hazards of overdose are greater in those with\u003cspan\u003e the \u003c\/span\u003enon-cirrhotic\u003cspan\u003e \u003c\/span\u003ealcoholic liver disease.\u003cbr\u003eDo not take more medicine than the label instructed. If the patient did not get better, talk to the physician.\u003cbr\u003eDo not take anything else containing paracetamol while taking Paracetamol-650.\u003cbr\u003eInform the physician at once if the patient\u003cspan\u003e \u003c\/span\u003etakes\u003cspan\u003e \u003c\/span\u003etoo much of Paracetamol-650, even if the patient\u003cspan\u003e \u003c\/span\u003efeels\u003cspan\u003e \u003c\/span\u003ewell. This is because too much paracetamol can cause delayed, serious liver damage.\u003cbr\u003ePatients should be advised that paracetamol may cause severe skin reactions. If a skin reaction eg, skin reddening, blisters or rash\u003cspan\u003e \u003c\/span\u003eoccur, they should stop use and seek medical assistance right away.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eUse In Pregnancy \u0026amp; Lactation\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eUse in pregnancy \u0026amp; lactation: Epidemiological studies in human pregnancy have shown no ill effects due to paracetamol used in the recommended dosage, but patients should follow the advice of the physician regarding its use. Paracetamol is excreted in breast milk but not in a clinically significant amount. Available published data do not contraindicate breastfeeding.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAdverse Reactions\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eAdverse effects of paracetamol are rare. Very rare cases of serious skin reactions have been reported. There have been reports of blood dyscrasias including thrombocytopenia purpura,\u003cspan\u003e \u003c\/span\u003emethemoglobinaemia\u003cspan\u003e, \u003c\/span\u003eand\u003cspan\u003e \u003c\/span\u003eagranulocytosis, but these were not necessarily causality related to paracetamol.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eInteractions\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eCholestyramine:\u003c\/em\u003e The speed of absorption of paracetamol is reduced by cholestyramine. Therefore, the cholestyramine should not be taken within 1 hr if maximal analgesia is required.\u003cbr\u003e\u003cem\u003eMetoclopramide and Domperidone:\u003c\/em\u003e The absorption of paracetamol is increased by metoclopramide and domperidone. However, concurrent use need not be avoided.\u003cbr\u003e\u003cem\u003eWarfarin:\u003c\/em\u003e The anticoagulant effect of warfarin and other coumarins may be enhanced by\u003cspan\u003e the \u003c\/span\u003eprolonged\u003cspan\u003e \u003c\/span\u003eregular use of paracetamol with increased risk of bleeding; occasional doses have no significant effect.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eChloramphenicol:\u003c\/em\u003e Increased plasma concentration of chloramphenicol.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCategory B\u003c\/strong\u003e: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1\u003csup\u003est\u003c\/sup\u003etrimester (and there is no evidence of a risk in later trimesters).\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStorage\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eStore below 30 C. Protect from light.\u003c\/p\u003e","brand":"Medlife","offers":[{"title":"15 Tabs","offer_id":20775286014065,"sku":"RANGOTS01A","price":16.8,"currency_code":"INR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0058\/5092\/3121\/products\/3D_Models-1c.jpg?v=1550134540","url":"https:\/\/medlifeessential.myshopify.com\/products\/medlife-paracetamol-650-mg-15tab-x-1s","provider":"MedlifeEssential","version":"1.0","type":"link"}